Firms, funds, partners, companies and rounds from sworn filings, firm sites and announcements, kept as a graph with a date and a source on every edge. Facts, inferences and estimates are labelled as such. A fund target is never a close, GAV is never dry powder, and a round size is never an investor’s check.

Firms / The Column Group

The Column Group

Multi-stage venture firmSan Francisco, CAthecolumngroup.comSEC venture capital fund adviserfundraising evidenceone firm, 2 filing advisers

This firm files as 2 advisers on thecolumngroup.com: TCG Labs. Each keeps its own CRD, funds and filings; the grouping is the website each swore to on Form ADV and is recomputed every pass.

The Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry.

both early and growth/opportunity families, reported GAV $4,215M

Importance
70
high
Active deployment
90
high
Emerging
0
low
Completeness
75
high
Freshness
100
high
Research priority
31
moderate
Identity and regulatory footprint
Headquarters
San Francisco, CAadviserinfo.sec.gov
Office address
ONE LETTERMAN DRIVE, BUILDING D, SUITE M-900, San Francisco, CA, 94129-1492adviserinfo.sec.gov
Business phone
415-865-2050adviserinfo.sec.gov
SEC adviser type
exempt reporting adviseradviserinfo.sec.gov
SEC exemption claimed
venture capital fund adviseradviserinfo.sec.govItem 2.B(1): advises solely venture capital funds
Latest Form ADV
Mar 19, 2026
Private funds reported
15 (15 venture capital funds)adviserinfo.sec.gov
Private fund gross assets
$3.3Badviserinfo.sec.govreported GAV of the funds, the adviser's own number; not fund size, not dry powder
Owners on Schedule A
The Column Group, LLC (General Partner), NA
business email
info@thecolumngroup.comthecolumngroup.compublished by the subject
business phone
415-865-2050adviserinfo.sec.govpublished by the subject
Stated thesis versus observed behaviour
39 observed deals
Stated (the firm’s website)
Sectors
biotech
Stages
early
Geography
not stated
Check size
not stated; DFX does not estimate checks from round sizes
Self-described
venture capital
Observed (from deals on record)
Stage at participation: no observed deals yet
Stage at first entry: no observed deals yet
Sectors
unknown 77%Biotechnology 19%Other 3%
lead rate n/afollow-on rate n/anew logos, 12 months 39
Funds and vehicles
15 reported
VehicleTypeVintageLifecycleReported GAVOwnersForm D soldLatest Form D
Column Group-Neuro II, LPFund2024 form d first saleEarly deploymentunknownunknown$100M
of $100M
Feb 13, 2024
The Column Group Opportunity III LPOpportunity fund2022 form d first saleActive deployment$652M
Mar 20, 2024
107$600M
of $600M
Jun 16, 2022
The Column Group V LPFund2022 form d first saleActive deployment$592M
Mar 20, 2024
106$600M
of $600M
Jun 16, 2022
The Column Group Spv I, LPSPV or co-invest vehicle2022 form d first saleActive deployment$10.4M
Mar 20, 2024
2$10.5M
of $10.5M
Dec 8, 2022
The Column Group - Neuro, LPFund2021 form d first saleMature$99.9M
Mar 20, 2024
8$100M
of $100M
May 14, 2021
The Column Group IV, LPFund2020 adv first reportedMature$1.1B
Mar 20, 2024
92$0
of $700M
Dec 11, 2019
The Column Group Iva LPFeeder or parallel2020 adv first reportedMature$32.5M
Mar 20, 2024
3$0
of $25.0M
Dec 11, 2019
Ponoi Capital II, LPFund2019 adv first reportedMature$385M
Mar 20, 2024
23$0
of $100M
Mar 6, 2018
Ponoi Capital LPFund2017 adv first reportedHarvest$434M
Mar 20, 2024
35$0
of $150M
Jun 7, 2017
The Column Group Iiia, LPFeeder or parallel2016 form d first saleHarvest$180M
Mar 20, 2024
41$271M
of $271M
Apr 27, 2016
The Column Group III, LPFund2016 form d first saleHarvest$160M
Mar 20, 2024
51$240M
of $240M
Apr 27, 2016
The Column Group II, LPFund2010 form d first saleHarvest$232M
Mar 20, 2024
64$65.5M
of $350M
Mar 10, 2010
The Column Group, LPFundunknownUnknown$377M
Mar 20, 2024
63unknownunknown
Column Group VI, LPFundunknownFundraisingunknownunknown$0
of $600M
Dec 16, 2025
Column Group Opportunity IV, LPOpportunity fundunknownFundraisingunknownunknown$0
of $600M
Dec 16, 2025
GAV is the gross asset value the adviser reported on Form ADV for the vehicle, never the fund’s committed size and never dry powder. Form D sold is the amount sold as of the latest filing, never a final close.
Investment team
36 current, 5 departed
Kristen Steele Hunter
Director, Portfolio Finance & Operations
Platform and operations
5 departed (kept with end dates)
  • Harald Jan Michael Ekman · Limited Partner Of Fund Gp Spv Only · Oct 1, 2012 to Mar 20, 2013 Inference
  • Eikon Therapeutics · Science Partner · ? to Sep 16, 2026 Inference
  • Kevin Moses · Partner · Sep 1, 2016 to May 8, 2017 Inference
  • Laurence a. Lasky · Partner (The Column Group Management Lp) · May 1, 2014 to Jan 15, 2020 Inference
  • Robert Tjian · Discovery Partner (Ponoi Management, Llc) · Jun 1, 2017 to Mar 29, 2019 Inference
Investments on record
39 edges, 31 companies, 0 partner-attributed
CompanyRoundRolePartnerRound sizeThis investorDateSource
A2 Biotherapeuticsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Aragon Pharmaceuticalsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Arcus Biosciencesportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Atavistik Bioportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Carmot Therapeuticsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Circle Pharma, Inc.portfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Constellation Pharmaceuticalsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Escient Pharmaceuticalsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Flexus Biosciencesportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Gritstone Bioportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Hexagon Bioportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Immune Designportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Judo Bio Inc.portfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Kallyopeportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Lyterian Therapeuticsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Neurona Therapeutics, Incportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Ngm Bioportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Nura Bioportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Oric Pharmaceuticals, Inc.portfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Peloton Therapeuticsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Plexium, Inc.portfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
RAPT Therapeutics, Inc.portfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Revolution Medicinesportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Seragon Pharmaceuticalsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Surrozenportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Synthekineportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
SyntheX,Inc.portfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Tenaya Therapeuticsportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Tortugas Neuroscienceportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Tr1x Bioportfolio listingunknownunknownunknownunknownSep 16, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Circle Pharma, Inc.portfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Johnson and Johnsonportfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Judo Bio Inc.portfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Kallyopeportfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Neurona Therapeutics, Incportfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Oric Pharmaceuticals, Inc.portfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
Plexium, Inc.portfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
RAPT Therapeutics, Inc.portfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
SyntheX,Inc.portfolio listingunknownunknownunknownunknownSep 12, 2026Fact Venture organization websites (about, team, portfolio, thesis, news pages)
“This investor” is the amount disclosed for this investor alone; it is unknown unless a source said it. The round size is the whole round.
Co-investors
15 relationships from shared deals, counted for the whole firm
Limited partners
0 disclosed
No LP commitment on record. An LP edge needs a public disclosure with a quote: a pension report (see Limited partners for the plans read), a fund announcement naming the LP, or a Form ADV owner. The fund page carries the LP’s reported performance.
Timeline
23 dated events
  1. Sep 16, 2026
    Johnson and Johnson no longer listed on The Column Group's portfolio page
  2. Sep 16, 2026
    Eikon Therapeutics (Science Partner) no longer on the team page of The Column Group
  3. Mar 17, 2023
    The Column Group V LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $608,034,807
  4. Mar 17, 2023
    The Column Group Spv I, LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $10,396,044
  5. Mar 17, 2023
    The Column Group Opportunity III LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $602,428,062
  6. Mar 28, 2022
    The Column Group - Neuro, LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $99,803,372
  7. Mar 27, 2020
    The Column Group Iva LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $17,929,292
  8. Mar 27, 2020
    The Column Group IV, LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $707,070,707
  9. Jan 15, 2020
    Laurence a. Lasky (Partner (The Column Group Management Lp)) no longer on Schedule A of The Column Group
  10. Mar 29, 2019
    Ponoi Capital II, LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $154,572,491
  11. Mar 29, 2019
    Robert Tjian (Discovery Partner (Ponoi Management, Llc)) no longer on Schedule A of The Column Group
  12. Jul 20, 2017
    Ponoi Capital LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $175,000,000
  13. May 8, 2017
    Kevin Moses (Partner) no longer on Schedule A of The Column Group
  14. Mar 28, 2017
    The Column Group III, LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $247,641,211
  15. Mar 28, 2017
    The Column Group Iiia, LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $279,674,070
  16. Sep 1, 2016
    Robert Tjian joined Schedule A of The Column Group as Discovery Partner (The Column Group Iii Management Lp)
  17. Sep 1, 2016
    Kevin Moses joined Schedule A of The Column Group as Partner
  18. May 6, 2014
    The Column Group II, LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $206,641,000
  19. May 1, 2014
    Laurence a. Lasky joined Schedule A of The Column Group as Partner, The Column Group Ii Management Lp
  20. Mar 20, 2013
    Harald Jan Michael Ekman (Limited Partner Of Fund Gp Spv Only) no longer on Schedule A of The Column Group
  21. Jun 1, 2012
    James Philip Evangelista joined Schedule A of The Column Group as Director Of Finance
  22. Mar 30, 2012
    The Column Group first filed Form ADV (ERA, venture capital fund adviser exemption)
  23. Mar 30, 2012
    The Column Group, LP first reported on Form ADV by The Column Group (Venture Capital Fund), GAV $238,545,544
Classification history
  1. Sep 15, 2026
    Multi-stage venture firm (confirmed, 95%, cls-1)
    both early and growth/opportunity families, reported GAV $4,215M
  2. Sep 12, 2026
    Multi-stage venture firm (confirmed, 95%, cls-1)
    both early and growth/opportunity families, reported GAV $3,838M
Evidence
64 observations from 4 sources
Every observation behind this profile, with its source, date and class
FactValueEffectiveClassSource
Why admittedvc_exemption,vc_funds_reportedMar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
SEC exemption claimedventure_capital_fund_adviserMar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
SEC exemption claimedventure_capital_fund_adviserMar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
SEC adviser typeexempt_reporting_adviserMar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
SEC adviser typeexempt_reporting_adviserMar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
First Form ADV filing2012-03-30Mar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Adv history loadedadv-hist-1Sep 12, 2026FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Latest Form ADV filing2026-03-19Mar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
Latest Form ADV filing2024-03-20Mar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
SEC statusERA - ActiveMar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
SEC status effective2012-03-30Mar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
Venture share of reported funds1Mar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Business phone415-865-2050Mar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
Business phone415-865-2050Mar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Contact page urlhttps://www.thecolumngroup.com/contact/
contact page linked from the home page
Sep 16, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
DescriptionThe Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry.
meta description
Sep 16, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
DescriptionThe Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry.
meta description
Sep 12, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
HeadquartersSan Francisco, CAMar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
HeadquartersSan Francisco, CAMar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Office addressONE LETTERMAN DRIVE, BUILDING D, SUITE M-900, San Francisco, CA, 94129-1492Mar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
Office addressONE LETTERMAN DRIVE, BUILDING D, SUITE M-900, San Francisco, CA, 94129-1492Mar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Self-described typeventure_capital
TCG takes a novel approach to venture capital funding with an edge-to-edge investment model primarily focused on company formation but with the financial wherewithal for long-term private and public c
Sep 16, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Self-described typeventure_capital
TCG takes a novel approach to venture capital funding with an edge-to-edge investment model primarily focused on company formation but with the financial wherewithal for long-term private and public c
Sep 12, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Legal formLimited PartnershipMar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
Legal formLimited PartnershipMar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Portfolio pagehttps://www.thecolumngroup.com/portfolio/
30 entries read
Sep 16, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Portfolio pagehttps://www.thecolumngroup.com/portfolio/
30 entries read
Sep 12, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Private funds reported15Mar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
Private funds reported12Mar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Private fund gross assets (reported)$3.3BMar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
Private fund gross assets (reported)$4.2BMar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Schedule a diffsadiff-1Mar 19, 2026FactIAPD Form ADV Part 1 PDF per firm (current filing, Schedule D 7.B.(1) and Schedule A)
Stated sectorsbiotech
sector words on the home page
Sep 16, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Stated sectorsbiotech
sector words on the home page
Sep 12, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Stated stagesearly
stage words on the home page
Sep 16, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Stated stagesseries_b,early
stage words on the home page
Sep 12, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Team pagehttps://www.thecolumngroup.com/tcg-team/
29 name/title pairs read
Sep 16, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Team pagehttps://www.thecolumngroup.com/tcg-team/
25 name/title pairs read
Sep 12, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Venture funds reported15Mar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
Venture funds reported12Mar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
WebsiteHTTP://WWW.THECOLUMNGROUP.COMMar 19, 2026FactSEC Form ADV monthly roster (registered + exempt reporting advisers)
WebsiteHTTP://WWW.THECOLUMNGROUP.COMMar 20, 2024FactSEC Form ADV filing data 2011 to 2024 (every filing, Schedule D 7.B.(1) private funds, Schedules A/B)
Site titleThe Column Group | TCG
title tag
Sep 16, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)
Site titleThe Column Group | TCG
title tag
Sep 12, 2026FactVenture organization websites (about, team, portfolio, thesis, news pages)